Dr. Laurie Alpert, ND

Episode Summary

Can perimenopause cause anxiety, depression and mood swings—and does every woman need hormone replacement therapy or antidepressants to manage them?

In this episode of Girls Gone Wellness, Jeanette Titus and Victoria Gasparini are joined by Dr. Laurie Alpert, ND, a naturopathic doctor with a clinical interest in mental health, sleep and hormonal transitions. Together, they explore how perimenopause and menopause can affect women's mental health, including anxiety, depression, irritability, sleep disturbances, hormonal fluctuations and changes in sexual health.

Dr. Alpert begins by explaining how to recognize the early signs of perimenopause. While hot flashes and night sweats are commonly associated with menopause, changes in menstrual cycle length, worsening premenstrual syndrome (PMS), mood changes and changes in menstrual bleeding may appear earlier. She discusses the clinical criteria used to identify perimenopause, including variations in menstrual cycle length, and explains why some women experience symptoms before meeting these criteria.

A major focus of the conversation is the relationship between estrogen fluctuations, perimenopause and mental health. Dr. Alpert explains how sensitivity to hormonal changes may contribute to worsening PMS, anxiety, irritability, emotional sensitivity and depressive symptoms. However, hormones are only part of the picture. Insomnia, night sweats, fatigue, cognitive changes, relationship difficulties and the stress of caring for children or aging parents can also affect psychological well-being.

The episode distinguishes between temporary mood changes, depressive symptoms and major depressive episodes. Dr. Alpert discusses screening for mental health concerns using the Menopause Rating Scale (MRS), a validated questionnaire that assesses common menopausal symptoms, including psychological and physical concerns. Importantly, she challenges the misconception that depression and anxiety are inevitable during perimenopause.

What are the best treatment options for perimenopause-related mood changes? The conversation examines selective serotonin reuptake inhibitors (SSRIs), antidepressants and other medications sometimes described as neuromodulators. Dr. Alpert explains why these medications may be appropriate for some women, including their potential roles in managing depressive symptoms, hot flashes and sleep disturbances.

Menopausal hormone therapy (MHT), also known as hormone replacement therapy (HRT), is another major topic. Dr. Alpert discusses when hormone therapy may be considered, particularly for moderate to severe vasomotor symptoms such as hot flashes and night sweats. She addresses individualized risk-benefit assessments, breast cancer concerns, the timing of treatment initiation and how long someone may remain on hormone therapy. The conversation also covers local hormone therapy for genitourinary syndrome of menopause (GSM), including vaginal dryness and painful intercourse.

Sexual health, body image and relationships are explored as important but frequently overlooked aspects of perimenopause. Dr. Alpert discusses changes in libido, sexual discomfort, relationship stress, weight changes and the potential re-emergence of disordered eating patterns. She emphasizes the importance of partner support, communication and addressing sexual health concerns rather than accepting discomfort as an unavoidable consequence of aging.

The episode also addresses fertility and contraception during perimenopause. Dr. Alpert explains why pregnancy remains possible before menopause and why menopausal hormone therapy does not provide contraception. Hormonal intrauterine devices (IUDs) and oral contraceptives are discussed as potential options depending on individual needs, including the management of heavy menstrual bleeding.

Finally, the conversation explores practical ways to prepare for and navigate perimenopause, including menstrual cycle tracking, regular exercise, sleep, social connection and nutrition. Dr. Alpert discusses Mediterranean-style eating patterns, dietary fibre, protein, soy consumption and the limitations of exercise as a direct treatment for hot flashes. She also challenges restrictive dietary advice and the misconception that women experiencing menopause should abandon cardiovascular exercise in favour of strength training alone.

Throughout the episode, Dr. Alpert emphasizes individualized, evidence-informed care and shared decision-making. Her central message is that although perimenopause can bring physical and psychological changes, significant suffering should not be treated as an inevitable part of the transition.





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Dr. Brennan Dedecker, ND

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Dr. Dominique Vanier, ND